"I drank water and took insulin
Diabetic misery was the mother of invention
Tommy Ritz (right) checks his AI driven insulin pump during a discussion with William Mary's tech transfer director Jason McDevitt. They've put canada goose jacket outlet sale together a company, Auxulin, and want to bring to market a new drug that alleviates hyperglycemic episodes. (WYDaily/Courtesy of Joseph McClain)
Tommy canada goose coats uk Ritz began injecting himself with insulin when he was 5.
"It was the norm," he said. "It helped that my dad had been a diabetic since he was 25, so it wasn too weird to have to give myself injections and prick my finger. By 6 or canada goose uk black friday 7, I was managing it by myself."
Ritz is a student in the class of 2019 canada goose outlet black friday MBA program at William Mary's Raymond A. MasonSchool of Business. He and his father are Type 1 diabetics. They have an idea for a drug designed to alleviate https://www.outletmoncler.de the misery of hyperglycemic episodes that Type 1 diabetics experience many times a week. Jason McDevitt is helping Ritz and his dad take their discovery to market.
McDevitt is William Mary's director of technology transfer. He has helped Ritz form a company, Auxulin, and has secured intellectual property rights for the drug, which carries the working title Aux 101.
The idea behind Aux 101 came to Ritz in the winter of 2016 on the day following a hyperglycemic episode that saw his blood sugar soar to 500.
"That a level that usually requires hospitalization, but I didn go," Ritz said. "I drank water and took insulin, enough to get it down over the course of the night. patents to drugs in the development pipeline. They made deep, deep dives into academic medical journals and came up empty but they were able to identify a few potential approaches to a solution.
McDevitt and Ritz are both understandably close mouthed about details of Aux 101, but share some information. It's a variation of a canada goose outlet prescription drug that is off patent and not widely used. McDevitt explained that the substance should be classified as a 505(b)(2) drug.
"Technically, this is a new use of an old drug," McDevitt said. "We taking an old drug that is off patent, changing the formulation, and using it for something different. The 505(b)(2) designation refers to the particular code of law that potentially allows you to get a drug to market more quickly."
Since the drug is available, it means that limited human testing for this new use could begin immediately. The Ritzes tested the drug on themselves when they were having hyperglycemic episodes.
30 60 hyperglycemic episodes a month
Hyperglycemia is defined as a glucose level of 250 mg/dL (milligrams per deciliter of blood) or above. Ritz said he has between 30 to 60 hyperglycemic periods each month. The episodes are of varying severity. He points out that he is healthy for a Type 1 diabetic and keeps a close eye on his levels.
"I exercise every day, and I have a restrictive diet," Ritz said. "I have a new insulin pump it has artificial intelligence in it to help canada goose online uk reviews regulate my blood sugar. My glucose levels are better controlled than the average diabetic, and I still having this happen twice a day. So, if I an example of a canada goose gilet uk sale patient who exhibits good canada goose outlet website review blood glucose management, there going to be a lot of people for whom this is going to be an even greater issue."
Type 1 diabetics can become resistant to their injected insulin during hyperglycemic episodes. And Ritz said that canada goose outlet near me the higher the blood sugar level, the more likely the body is to become insulin resistant. Further, the longer a diabetic is hyperglycemic, the greater their risk of hospitalization and developing dangerous long term complications.
"Say my blood sugar is 300; I take three units of insulin. The level doesn move. I take another two; it not moving," he said. cheap canada goose uk "Take another one. It not moving. Finally, it drops after I taken seven or eight units of insulin over the course of several hours.
"But if I take that initial correction dose of three units along with Aux 101, that all I need," Ritz added. In addition to overcoming the body's insulin resistance, Aux 101 slashes the time it takes for his blood sugar to return to normal: 45 minutes, rather than the two to three hours.
It may reduce insulin usage
In addition canada goose outlet to the reduction in time to get blood sugar back to normal, Aux 101 may reduce canada goose sale outlet review insulin usage, a potentially important benefit given the rising costs of insulin medications.
Aux 101 is administered orally. As currently formulated, it's meant only to mitigate the physiological effects of hyperglycemia not as a replacement for daily insulin maintenance.
Ritz said he and his father established a testing regimen. When their blood sugar was high, they would take an injection of insulin, then check their levels every 15 minutes until it was below 180. To get more accurate readings, they used an actual blood sugar machine, rather than a constant glucose monitor.
"At this point, it not like it works 10 percent of the time," he said. "Every time, it has worked to reduce our blood sugars from a hyperglycemic level to a normal range, sometimes three times faster than just taking insulin alone."
Ritz said he came to business school at William Mary in part to take advantage of the business school'sExecutive Partnersnetwork, to get some guidance in how to take the canada goose outlet kokemuksia drug to market and in developing a commercialization strategy
"I got a lot of good advice, but a lot of people didn understand it or feel comfortable enough with the science behind it to move forward," he said. Then one day he was talking with Graham amazon uk canada goose Henshaw, the executive director of the school's Alan B. Miller Entrepreneurship Center.
"Graham asked me if I had talked to Jason at the canada goose victoria uk tech transfer office," Ritz recalled. "I said no, so I decided to set up a meeting with him. In our initial conversation, Jason immediately understood the potential, and we just moved forward from there."
William Mary's a stakeholder in Auxulin
William Mary has invested in Auxulin, providing funding to secure the intellectual property rights as well as for McDevitt's expertise. As a stakeholder, the canada goose outlet online university stands to gain financially from the market success of Aux 101.
McDevitt knows a great deal about the arcana of intellectual property laws, and he is familiar with 505(b)(2) drugs, having previously founded a company developing a new use of an old tuberculosis drug. He even used to work in a canada goose outlet paypal lab dedicated to Type 2 diabetes. But his dealings with Ritz opened his eyes to the day to day life of a Type 1 diabetic.